AS WE CONTINUE TO INCREASE OUR UNDERSTANDING OF THE HEALING CAPABILITIES OF CELLS CONTAINED IN OUR BODY, WE ARE DISCOVERING THE ROLE OF IMPORTANT GROWTH FACTORS AND CYTOKINES THAT FACILITATE HEALING AND REDUCE INFLAMMATION.  

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AT ORTHOREGEN®, OUR PROCESSING TECHNIQUES CONCENTRATE THESE GROWTH FACTORS AND CYTOKINES THAT ARE IMPORTANT IN HEALING, CELLULAR COMMUNICATIONS, REDUCING INFLAMMATION AND PROTECTING CARTILAGE IN JONTS. 

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OrthoRegen's® advanced growth factor concentrate or C-GF Therapy is an autologous blood product that concentrates anti-inflammatory proteins, called cytokines, using a specialised processing technique.  Using the Orthokine system developed in Germany, these protective cytokines inhibit the destructive effects of other inflammatory mediators.  Two of the major proteins we are able to concentrate are alpha-2-macroglobulin (A2M) and Interleukin-1 receptor antagonist (IL-1Ra).  Recent research has shown that these two proteins block destructive inflammatory cytokines in the joints of patients with osteoarthritis.  ​We have also found that our plasma concentrate contains a large number of exosomes, which are a potential game changer in regenerative medicine.

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Our C-GF therapy is a potent healer in regards to neurogenic inflammation and can reduce neuropathic pain and aid in healing nerve impingement or nerve damage due to trauma or compression.  We also utilise C-GF Therapy in combination with our other cellular treatments to treat many musculoskeletal conditions and injuries.

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Our C-GF therapy also contains Exosomes.  These small vesicles, once thought to be mere cellular debris, are now recognized as critical communicators in the body's own repair mechanisms. Exosomes are extracellular vesicles secreted by cells, including mesenchymal stem cells (MSCs) and platelets, which play a pivotal role in intercellular communication. They carry a cargo rich in proteins, mRNAs, and micro-RNAs, which can alter the behavior and function of recipient cells. This ability to transfer biomolecules between cells positions exosomes as potential therapeutic agents in regenerative medicine.

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The therapeutic potential of exosomes lies in their capacity to mimic the regenerative effects of stem cells without the associated risks and complexities. 

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In the realm of health, exosomes have been shown to aid in tendon regeneration, wound healing, and even incontinence treatment. Researchers from the Mayo Clinic Van Cleve Cardiac Regenerative Medicine Program are exploring how exosomes can be used to regenerate heart muscle after damage caused by a heart attack. This research is part of a broader effort to translate laboratory findings into potential cures and treatments for patients.

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Moreover, exosomes have demonstrated their ability to improve symptoms of sarcopenia and show potential in applications such as knee osteoarthritis, cartilage restoration, and tendon regeneration. These findings suggest that exosomes could be harnessed to promote repair and regeneration in targeted areas of the body, offering hope for those suffering from a range of degenerative conditions.

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The use of exosomes in regenerative medicine is not without its challenges. Further research is needed to fully understand the mechanisms by which exosomes promote tissue repair. Additionally, strategies for the effective delivery and targeting of exosomes must be developed to maximize their therapeutic potential.

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The future of regenerative medicine may very well rest within these microscopic messengers, carrying the promise of rejuvenation and repair.

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Today, with much research underway, the biological causes of osteoarthritis are much better understood. We now know it is not just mechanical cartilage wear but a complex disease that affects the entire joint. These destructive and aggressive messenger proteins play a pivotal role in the development of Osteoarthritis. It stimulates joint inflammation and destruction of articular cartilage by stimulating other destructive proteins in the joint.

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How to get started with C-GF therapy?

 

If you are interested in our C-GF therapy and want to find out if you are a good candidate, you can contact OrthoRegen® to schedule a consultation.  You can also visit our CONTACT PAGE to complete the new patient documentation, which will be reviewed by Dr Schiavo to see if we can help treat your condition.  OrthoRegen® will provide you with a comprehensive assessment and a personalised treatment plan that will help you achieve your health and wellness goals. 

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For further information on other services and treatments we provide, please head to OUR SERVICES page.

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